Does CBD have any side effects?
CBD is known to have potential for treating a wide array of health conditions. The cannabinoid is largely non-toxic, but does it have any side effects?
CBD is a natural chemical derived from the cannabis plant. The compound belongs to a classification known as cannabinoids, which are found both in cannabis (phytocannabinoids) and the human body (endocannabinoids). CBD has become incredibly well-known in recent years for its ability to assist in the treatment of symptoms of an entire host of illnesses and health conditions.
Of particular interest are the antioxidant, anti-inflammatory, neuroprotective, and anti-convulsant actions of the compound. CBD is a more potent neuroprotective antioxidant than both vitamin C and vitamin E. Research has also shown its effectiveness in treating cancer cells in vitro. Higher doses of the cannabinoid are postulated to be therapeutic for various psychiatric disorders such as schizophrenia and dementia. Research in the areas of diabetes and nausea also show potential.
Cannabis is known as a safe and natural medicine, with virtually zero deaths associated with its use. Research has rated the herb as the least dangerous substance when compared to substances such as alcohol and nicotine in regards to toxicity. The known risks associated with cannabis use inhabit the domains of mental illness. THC, the psychoactive constituent within the plant, has been linked to agitating mental conditions in some people.
However, CBD is often taken in an extracted and isolated form, derived from industrial hemp or low-THC strains. CBD is non-psychoactive, and has actually been shown to be antipsychotic.
CBD is generally regarded as safe. It exerts its effects on the body in a myriad of ways, acting upon the CB1 and CB2 receptors of the endocannabinoid system indirectly. It also interacts with serotonin, vanilloid, GPR55, and PPARs receptors.
Much like any other substance you could introduce to your biology, CBD has its own set of side effects. Although these aren’t necessarily serious, they are worth knowing if you take the cannabinoid, or plan on doing so in the future.
Possible negative side effects of CBD oil include:
- Dry Mouth: Many cannabis smokers out there will be familiar with the sensations of dry mouth. This usually occurs after smoking a few joints, leaving the feeling a cotton ball residing within the mouth. This can be easily remedied with a glass of water or juice.
Dry mouth occurs because cannabis decreases saliva secretion. Cannabinoid receptors of the endocannabinoid system exist within the salivary glands. CBD interacts with these receptors, causing the inhibition of salivary secretion, and thus inducing dry mouth. Just drink some water ;)
- Drowsiness: This typically only happens in extremely high doses.- Light-headedness: A drop in blood pressure is normally the culprit here. However, it is a temporary issue normally resolved by drinking a cup of tea or coffee.
- Increased Tremors in Parkinson’s Patients: According to preliminary research, very high doses of CBD could worsen muscle movement and tremor in Parkinson’s patients. However, others studies indicate that such individuals tolerate CBD rather well.
- Inhibition of Hepatic Drug Metabolism: CBD could inhibit the activity of liver enzymes known as cytochrome P450. This enzyme family metabolizes most pharmaceutical drugs and if you take high doses of CBD, it may neutralize P450 activity and change the way drugs are metabolized in your body. For the record, eating a small portion of grapefruit has a similar effect, so perhaps this isn’t one of the worst side effects of CBD oil! 😁
Cannabinoids such as CBD have been shown to be exceptionally non-toxic, with no fatalities reported. Large doses of up to 1500mg per day of CBD have been shown to be well-tolerated in human subjects. The Department of Health and Human Services states that no signs of toxicity or serious side effects are associated with chronic use of CBD in healthy individuals.